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Description
CD100/Semaphorin-4D Recombinant Rabbit mAb (S-3651-16)Product Specification Host Rabbit Antigen CD100 Semaphorin 4D Synonyms Semaphorin 4D; A8; BB18; GR3; C9orf164; SEMAJ; SEMA4D Immunogen Synthetic Peptide Location Cell membrane Accession Q92854 Clone Number S 3651 16 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Daudi, Jurkat, EL4, mouse thymus, rat thymus Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | CD100/Semaphorin-4D |
| Synonyms | Semaphorin-4D; A8; BB18; GR3; C9orf164; SEMAJ; SEMA4D |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q92854 |
| Clone Number | S-3651-16 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Daudi, Jurkat, EL4, mouse thymus, rat thymus |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms, Rt |
Background
CD100, also known as Semaphorin-4D (Sema4D), is a type I transmembrane glycoprotein belonging to the semaphorin family that functions as a critical bidirectional signaling molecule in both the nervous and immune systems. Originally identified for its role in axon guidance and neuronal development by repelling growth cones through its interaction with Plexin-B1 receptors, CD100 has since been recognized as a potent immunomodulator expressed on activated T cells, B cells, dendritic cells, and various tumor types. Upon cleavage by metalloproteinases, it releases a soluble form that retains biological activity, engaging primarily with Plexin-B1 on endothelial and tumor cells to promote angiogenesis, cell migration, and invasion, while also binding to CD72 on B cells to regulate their activation and differentiation. This dual functionality makes CD100/Sema4D a pivotal player in pathological processes such as tumor progression, metastasis, and inflammatory responses, thereby establishing it as a promising therapeutic target for cancer immunotherapy and autoimmune disease management.
Shipping Notes
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