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Description
p47phox Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen p47phox Synonyms Neutrophil cytosol factor 1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF 47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; NOXO2; SH3PXD1A; NCF1 Immunogen Synthetic Peptide Location Cytoplasm Accession P14598 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu Positive Sample Ramos, Raji, Daudi, H L60 Purification
Product Specification
| Host | Rabbit |
| Antigen | p47phox |
| Synonyms | Neutrophil cytosol factor 1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; NOXO2; SH3PXD1A; NCF1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P14598 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | Ramos, Raji, Daudi, H-L60 |
| Purification | Immunogen Affinity |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
Background
p47phox, also known as neutrophil cytosolic factor 1 (NCF1), is a critical 47-kDa cytosolic regulatory subunit of the NADPH oxidase enzyme complex (NOX2) that plays an indispensable role in the innate immune system's ability to generate reactive oxygen species (ROS) for microbial killing. Under resting conditions, p47phox resides in the cytoplasm in an autoinhibited state where its C-terminal SH3 domains interact with its own N-terminal region, but upon cellular stimulation by pathogens or inflammatory signals, it undergoes extensive phosphorylation on multiple serine residues within its unique "bisector" region; this conformational change exposes its SH3 domains, allowing p47phox to translocate to the plasma membrane and act as a molecular organizer or "adapter" that bridges the membrane-bound catalytic core (composed of gp91phox and p22phox) with the remaining cytosolic subunits (p67phox and p40phox) and the small GTPase Rac, thereby assembling the active oxidase complex responsible for the respiratory burst essential for host defense, with genetic deficiencies in p47phox leading to a specific variant of Chronic Granulomatous Disease (CGD) characterized by severe recurrent bacterial and fungal infections due to the failure of phagocytes to produce superoxide.
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