Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 4 - Jul 9
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
ERCC1 Recombinant Rabbit mAb,PBS Only (SDT-2458-29)Product Specification Host Rabbit Antigen ERCC1 Synonyms DNA excision repair protein ERCC 1 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession P07992 Clone Number SDT 2458 29 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample HeLa, HepG2, SK BR 3, MCF7, T 47D Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability &
Product Specification
| Host | Rabbit |
| Antigen | ERCC1 |
| Synonyms | DNA excision repair protein ERCC-1 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | P07992 |
| Clone Number | SDT-2458-29 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | HeLa, HepG2, SK-BR-3, MCF7, T-47D |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
| ICC | 1:2000 | Hu |
Background
ERCC1 (Excision Repair Cross-Complementation Group 1) is a 297-amino-acid protein that, together with its obligate partner XPF (ERCC4), forms a structure-specific heterodimeric endonuclease essential for nucleotide excision repair (NER) of helix-distorting DNA lesions caused by UV light or bulky adducts and for interstrand crosslink repair; the ERCC1–XPF complex incises the damaged DNA strand on the 5′ side of the lesion, enabling excision of a ~24–32-nt oligonucleotide, and its expression level or polymorphisms (e.g., C118T, C8092A) are extensively studied as predictive biomarkers for resistance to platinum-based chemotherapy in lung, ovarian, and other solid tumors because reduced ERCC1-mediated DNA repair enhances platinum-induced cytotoxicity.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy