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Description
Neutrophil Elastase Recombinant Rabbit mAb (S-R230)Product Specification Host Rabbit Antigen Neutrophil Elastase Synonyms Bone marrow serine protease, Elastase 2, Human leukocyte elastase (HLE), Medullasin, PMN elastase, ELANE, ELA2 Accession P08246 Clone Number S R230 Antibody Type Recombinant mAb Application WB, IHC P, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | Neutrophil Elastase |
| Synonyms | Bone marrow serine protease, Elastase-2, Human leukocyte elastase (HLE), Medullasin, PMN elastase, ELANE, ELA2 |
| Accession | P08246 |
| Clone Number | S-R230 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:500-1:2000 | null |
| IP | 1:50 | null |
Background
Neutrophil elastase is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Neutrophil elastase is secreted by neutrophils during inflammation, and destroys bacteria and host tissue. It also localizes to neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases. Neutrophil elastase is an important protease enzyme that when expressed aberrantly can cause emphysema or emphysematous changes. This involves breakdown of the lung structure and increased airspaces. Mutations of the ELANE gene cause cyclic and severe congenital neutropenia, which is a failure of neutrophils to mature. In 2019 study was confirmed that ELANE deletion does not cause neutropenia.
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4.3 ★★★★★
Based on 315 reviews
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Product Reviews
★★★★★ 3
Hydrating moisturizer with pleasant scent
Style: MULTIBALM
Update:
I’ve now used 2 sticks. I won’t be buying again. Although I like how convenient this moisturizer is, the price is too high for the amount you get. Also, going through another stick, I’ve noticed no signs that it helps with fine lines or wrinkles. This product is simply an on the go moisturizer or even a highlighter. But I can use castor oil and Vaseline for that. I had to deduct a star.
So far, this moisturizing stick has been a great and convenient addition to my routine. It glides on smoothly and has a light, pleasant scent. The formula is definitely hydrating and leaves my skin feeling soft.
It does go on a bit oily or greasy at first. If that bothers you, rubbing it in helps, though it doesn't absorb immediately—so expect a bit of shine for a while after application.
As a moisturizer, it works well and I would definitely recommend it for anyone looking for a quick, on-the-go option. I haven’t noticed any additional benefits yet (like long-term improvements in skin texture or tone), but it might be too early to say. I’ll update my review if anything changes with continued use.
I do have a couple of concerns. First, the price—it feels expensive for the amount of product you get. Second, I’ve seen some people compare this to Botox, and I’m not sure why. It’s definitely not a substitute, and expecting those kinds of results just isn’t realistic. Along those lines, the product name—“Wrinkle Bounce”—may be a little misleading. While it’s hydrating and may temporarily plump the skin, it doesn’t deliver dramatic wrinkle-reducing effects.
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Reviewed in the United States on June 2, 2025
★★★★★ 5
Youthful, even skin!
Style: MULTIBALM
I’m loving this stick! I almost sent it back after the first two days but I’m so glad I didn’t. This has really helped me look more refreshed. It’s def helped with shallow lines. Overall it’s made me skin more even. It’s very oily and it sits on your skin so I use it before bed. But I’ve noticed it’s helped balance my skin. I usually get really oily during the day but oddly as oily as this is it keeps my skin from getting oily during the day under my makeup. My makeup looks more even. It’s just overall been great for my skin and it’s made me look younger. Def recommend!
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Reviewed in the United States on May 21, 2026
★★★★★ 4
Wrinkles: Meh, KP: Yeah!
Style: MULTIBALM, Style: MULTIBALM
An okay moisturizer. Very shiny. Scent is old fashioned - kind of a floral baby powder scent. Takes a while to soak in which is by design since it only fills in the wrinkles instead of plumping them. The illusion is in the shine. You can see from my photos that in certain light the wrinkles appear slightly diminished due to the shine but you can clearly see they are still there in the shadows. While this example is on my hand, I had the same results under my eyes and on my forehead. I let the product soak in for 5 minutes in these photos. On the upside it worked temporary wonders on my KP!
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Reviewed in the United States on May 19, 2026
★★★★★ 5
From dry to soft in days.
Style: 3.38 Fl Oz (Non SPF)
I bought this moisturizer at a time when my skin truly needed help, with mature and sensitive skin, and I was dealing with intense dryness. My skin felt tight, dull, and uncomfortable, even after trying several products that didn’t provide lasting hydration.
I decided to try this cream and within the first few days, I noticed a real difference. It’s lightweight, absorbs quickly, doesn’t feel greasy, and most importantly, it doesn’t irritate my skin—instead, it soothes it. With continued use, my skin became softer, more supple, and visibly healthier, without that constant tight feeling.
I love that it’s fragrance-free, oil-free, and non-comedogenic, as it hasn’t caused any breakouts. It also contains ceramides and niacinamide, and the added SPF makes my routine much easier. After trying many products, I can honestly say this is the only one that truly worked for me. It’s now a daily essential.
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Reviewed in the United States on April 18, 2026
★★★★★ 5
The best
Style: 3.38 Fl Oz (Non SPF)
I’ve been using the La Roche-Posay Toleriane Double Repair Face Moisturizer for a few weeks now, and it’s honestly one of the best daily moisturizers I’ve tried—especially for sensitive skin.
First thing I noticed is how lightweight it feels. It absorbs quickly and doesn’t leave that greasy or heavy film that a lot of “hydrating” lotions do. My skin feels instantly softer, but not suffocated. It layers really well under makeup too—no pilling or weird texture.
What really stands out is how balanced my skin has been since using it. I tend to get dry patches but also occasional breakouts, and this somehow helps with both. It hydrates without clogging pores, and I’ve noticed less redness overall. The fact that it contains ceramides and niacinamide is a huge plus if you’re trying to repair your skin barrier.
It’s also fragrance-free, which I personally look for because anything scented tends to irritate my skin.
The only small downside is the price point compared to drugstore moisturizers, but honestly, a little goes a long way and the quality makes it worth it.
Overall, I’d definitely recommend this if you have sensitive, combination, or dry skin and want something simple but effective. It’s become a staple in my routine.
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Reviewed in the United States on April 20, 2026